Mentalizing in schizophrenia: A multivariate functional MRI study

Mentalizing impairment in schizophrenia: a functional MRI study.

BACKGROUND A deficit in Theory of mind (ToM) or 'mentalizing' has been purported to underlie the poor social functioning seen in patients with schizophrenia. To understand the neural basis of this deficit studies have primarily used tasks requiring 'off-line' or explicit mentalizing but, in daily life, successful social interactions depend upon implicit or 'on-line' mentalizing. Therefore in th...

Brain Correlates of Self-Evaluation Deficits in Schizophrenia: A Combined Functional and Structural MRI Study

Self-evaluation plays an important role in adaptive functioning and is a process that is typically impaired in patients with schizophrenia. Underlying neural mechanisms for this dysfunction may be associated with manifested psychosis. However, the brain substrates underlying this deficit are not well known. The present study used brain blood oxygen level dependent (BOLD) functional magnetic res...

Cerebral responses to vocal attractiveness and auditory hallucinations in schizophrenia: a functional MRI study

Impaired self-monitoring and abnormalities of cognitive bias have been implicated as cognitive mechanisms of hallucination; regions fundamental to these processes including inferior frontal gyrus (IFG) and superior temporal gyrus (STG) are abnormally activated in individuals that hallucinate. A recent study showed activation in IFG-STG to be modulated by auditory attractiveness, but no study ha...

Abnormal brain connectivity in schizophrenia and bipolar disorder – a resting state functional MRI study

Effective connectivity of the multiplication network: a functional MRI and multivariate Granger Causality Mapping study.

Developmental neuropsychology and functional neuroimaging evidence indicates that simple and complex mental calculation is subserved by a fronto-parietal network. However, the effective connectivity (connection direction and strength) among regions within the fronto-parietal network is still unexplored. Combining event-related fMRI and multivariate Granger Causality Mapping (GCM), we administer...